UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P27931
Entry Name

IL1R2_MOUSE
Protein Name

Interleukin-1 receptor type 2
Primary Gene Name

Il1r2
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name IL-1RII
Cell Type endothelial cell, monocytes, lymphocytes
Substrate Description Leukocyte Recruitment - Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor
Sheddase ADAM17
Shedding-related Disease cytokine receptor
Short Summary of Papers soluble receptor antagonist,prevent IL-1 precursor processing
Cleavage Information NONE
PMID 16565325 10210771



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		14 355
Transmembrane
 		356 381



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER KEVS*STFS 357 ADAM8, ADAM17 NONE 16542157   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825