UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P27930
Entry Name

IL1R2_HUMAN
Protein Name

Interleukin-1 receptor type 2
Primary Gene Name

IL1R2
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name IL-1RII
Cell Type endothelial cell, monocytes, lymphocytes
Substrate Description Leukocyte Recruitment - Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor
Sheddase ADAM17
Shedding-related Disease cytokine receptor
Short Summary of Papers soluble receptor antagonist,prevent IL-1 precursor processing
Cleavage Information NONE
PMID 16565325 10210771



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		14 343
Transmembrane
 		344 369



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information neutrophil elastase NONE 10210771   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836
HCSD cancer (lung cancer) 19776420
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137