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| UniProt ID |
P27487 |
|
| Entry Name |
DPP4_HUMAN |
|
| Protein Name |
Dipeptidyl peptidase 4 |
|
| Primary Gene Name |
DPP4 |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Secreted |
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|---|
| Substrate Name | Dipeptidyl peptidase 4 (CD26,DPP4) | |
| Cell Type | ||
| Substrate Description | cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | MMP1, MMP2, MMP9, MMP14 | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | shedding of immune complexes (containing DPP IV) into vascular and extravascular fluids results in loss of DPP IV from the cell surface. may have relevance to hyperacute rejection; shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells. | |
| Cleavage Information | NONE | |
| PMID | 8878393 25217834 |
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Start | End |
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7 | 28 |
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29 | 766 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | MMP1,MMP2,MMP9,MMP14 | 25217834 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Tear | 16901338 | |
| Sys-BodyFluid | Urine | 17022654 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 18795103 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(lung cancer) | 21806062 | |