UniProt Summary
UniProt ID

P26992

Entry Name

CNTFR_HUMAN

Protein Name

Ciliary neurotrophic factor receptor subunit alpha

Primary Gene Name

CNTFR

Organism

Homo sapiens (Human)

Molecular Function

Receptor

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name ciliary neurotrophic factor receptor subunit alpha
Cell Type
Substrate Description binds to CNTF. CNTF is a survival factor for various neuronal cell types.
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cell receptor (CNTFR)
Short Summary of Papers CNTFR is cleaved from the cell surface and detected in cerebrospinal fluid and serum. CNTFR is released from skeletal muscle in response to peripheral injury.
Cleavage Information GPI-anchor
PMID 7681218



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 7681218   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16948836