UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P25445
Entry Name

TNR6_HUMAN
Protein Name

Tumor necrosis factor receptor superfamily member 6
Primary Gene Name

FAS
Organism

Homo sapiens (Human)
Molecular Function

Receptor
Calmodulin-binding
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Fas(CD95)
Cell Type
Substrate Description receptor for TNFSF6/FASLG, caspase-8 mediated apoptosis
Substrate Function Category disease
Substrate Function Subtype
Sheddase MMP7
Shedding-related Disease cancer (tumor escape)
Short Summary of Papers cleavage of CD95 by MMP-7 from the surface of the tumour cell may be a apoptosis resistant mechanism for tumour cells
Cleavage Information NONE
PMID 15077180



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		26 173
Transmembrane
 		174 190



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
ASCENT LSSK*SVNA 21 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
MEROPS KGLE*LRKT 36 matrix metallopeptidase-7 physiologically relevant NONE 15077180   
PMAP KGLE*LRKT 36 matrix metallopeptidase-7 This entry is based on an experiment 15077180   
MEROPS ETQN*LEGL 48 matrix metallopeptidase-7 physiologically relevant NONE 15077180   
PMAP ETQN*LEGL 48 matrix metallopeptidase-7 This entry is based on an experiment 15077180   
ASCENT CTVN*GDEP 76 UNKNOWN subtiligase-based N-terminal sequencing 33536314   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer(prostate cancer) 22908226
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 24418523
HCSD cancer(breast cancer) 24505115
HCSD cancer(Liver metastasis in colorectal cancer) 23443137