UniProt Summary
UniProt ID

P25118

Entry Name

TNR1A_MOUSE

Protein Name

Tumor necrosis factor receptor superfamily member 1A

Primary Gene Name

Tnfrsf1a

Organism

Mus musculus (Mouse)

Molecular Function

Receptor

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name TNFRI
Cell Type endothelial cell, monocytes, lymphocytes, neutrophils
Substrate Description Leukocyte Recruitment, Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor
Sheddase ADAM17, NE(neutrophil elastase)
Shedding-related Disease cytokine receptor
Short Summary of Papers receptor down-regulation,soluble TNF antagonist
Cleavage Information NONE
PMID 16565325



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
30 212
Transmembrane
213 235



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER TNPQ*DSGT 207 metalloprotease,ADAM17 16542157   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER macrophage 24396086
SPD 22728825