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| UniProt ID |
P25116 |
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| Entry Name |
PAR1_HUMAN |
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| Protein Name |
Proteinase-activated receptor 1 |
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| Primary Gene Name |
F2R |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | protease-activated receptor-1 (PAR1) | |
| Cell Type | ||
| Substrate Description | G protein-coupled receptors (GPCRs) activated by proteolysis. receptor for activated thrombin coupled to G proteins, platelets activation and in vascular development | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | ADAM17 | |
| Shedding-related Disease | cell receptor (GPCR) | |
| Short Summary of Papers | regulated shedding reduced the amount of cell surface PAR1 available for productive cleavage by thrombin by half or more | |
| Cleavage Information | NONE | |
| PMID | 14982936 |
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Start | End |
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42 | 102 |
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103 | 128 |
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138 | 157 |
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158 | 176 |
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177 | 198 |
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219 | 239 |
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240 | 268 |
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269 | 288 |
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312 | 334 |
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335 | 350 |
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351 | 374 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | ARTR*ARRP | 25 | Prothrombin | 10978167 | ||||
| MEROPS | ARTR*ARRP | 25 | thrombin | physiologically relevant | NONE | 10978167 | ||
| MEROPS | ARTR*ARRP | 25 | signal peptidase complex (animal) | physiologically relevant | NONE | 10978167 | ||
| HPRD | PESK*ATNA | 32 | Plasminogen; Calpain, large polypeptide L1; | 10978167 | ||||
| MEROPS | PESK*ATNA | 32 | calpain-1 | not physiologically relevant | NONE | 10978167 | ||
| MEROPS | PESK*ATNA | 32 | plasmin | physiologically relevant | NONE | 10978167 | ||
| HPRD | ATNA*TLDP | 36 | Elastase, leukocyte; Proteinase 3; | 10978167 | ||||
| MEROPS | ATNA*TLDP | 36 | elastase-2 | physiologically relevant | NONE | 10978167 | ||
| MEROPS | ATNA*TLDP | 36 | myeloblastin | physiologically relevant | NONE | 10978167 | ||
| HPRD | LDPR*SFLL | 41 | Plasminogen; Cathepsin G; Prothrombin; | 10978167 10644723 10978167 | ||||
| MEROPS | LDPR*SFLL | 41 | granzyme B (Homo sapiens-type) | not physiologically relevant | Mass spectroscopy | 8947506 | ||
| MEROPS | LDPR*SFLL | 41 | trypsin 1 | not physiologically relevant | NONE | 10978167 | ||
| MEROPS | LDPR*SFLL | 41 | kallikrein 1 | not physiologically relevant | N-terminal sequencing | 8947506 | ||
| MEROPS | LDPR*SFLL | 41 | coagulation factor Xa | not physiologically relevant | N-terminal sequencing | 8947506 | ||
| MEROPS | LDPR*SFLL | 41 | protein C (activated) | not physiologically relevant | N-terminal sequencing | 8947506 | ||
| MEROPS | LDPR*SFLL | 41 | thrombocytin | not physiologically relevant | NONE | 10908720 | ||
| MEROPS | LDPR*SFLL | 41 | matrix metallopeptidase-1 | physiologically relevant | NONE | 15707890 | ||
| MEROPS | LDPR*SFLL | 41 | kallikrein-related peptidase 5 | physiologically relevant | NONE | 16885167 | ||
| MEROPS | LDPR*SFLL | 41 | kallikrein-related peptidase 14 | physiologically relevant | NONE | 16885167 | ||
| MEROPS | LDPR*SFLL | 41 | elastase-2 | physiologically relevant | NONE | NONE | ||
| MEROPS | LDPR*SFLL | 41 | cathepsin G | physiologically relevant | NONE | 10978167 | ||
| MEROPS | LDPR*SFLL | 41 | granzyme A | physiologically relevant | NONE | NONE | ||
| MEROPS | LDPR*SFLL | 41 | tryptase alpha | physiologically relevant | NONE | 9020112 | ||
| MEROPS | LDPR*SFLL | 41 | mesotrypsin | physiologically relevant | NONE | 17623652 | ||
| MEROPS | LDPR*SFLL | 41 | platelet-aggregating venom peptidase | physiologically relevant | NONE | NONE | ||
| MEROPS | LDPR*SFLL | 41 | thrombin | physiologically relevant | NONE | 10978167 | ||
| MEROPS | LDPR*SFLL | 41 | plasmin | physiologically relevant | NONE | 10978167 | ||
| MEROPS | LDPR*SFLL | 41 | kallikrein-related peptidase 6 | physiologically relevant | NONE | 16885167 | ||
| MEROPS | LDPR*SFLL | 41 | unknown peptidase | physiologically relevant | NONE | 18331590 | ||
| PMAP | LDPR*SFLL | 41 | tryptase alpha | This entry is based on an experiment | Mass spectrometry | 9020112 | ||
| PMAP | LDPR*SFLL | 41 | kallikrein hK14 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| PMAP | LDPR*SFLL | 41 | kallikrein hK6 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| PMAP | LDPR*SFLL | 41 | kallikrein hK5 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| MEROPS | DPRS*FLLR | 42 | kallikrein-related peptidase 6 | physiologically relevant | NONE | 16885167 | ||
| PMAP | DPRS*FLLR | 42 | kallikrein hK6 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| HPRD | PRSF*LLRN | 43 | Prothrombin; Cathepsin G; | 10978167 | ||||
| MEROPS | PRSF*LLRN | 43 | chymotrypsin A (cattle-type) | not physiologically relevant | N-terminal sequencing | 8947506 | ||
| MEROPS | PRSF*LLRN | 43 | kallikrein-related peptidase 5 | physiologically relevant | NONE | 16885167 | ||
| MEROPS | PRSF*LLRN | 43 | kallikrein-related peptidase 14 | physiologically relevant | NONE | 16885167 | ||
| MEROPS | PRSF*LLRN | 43 | cathepsin G | physiologically relevant | NONE | 10978167 | ||
| MEROPS | PRSF*LLRN | 43 | kallikrein-related peptidase 6 | physiologically relevant | NONE | 16885167 | ||
| PMAP | PRSF*LLRN | 43 | kallikrein hK14 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| PMAP | PRSF*LLRN | 43 | kallikrein hK6 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| PMAP | PRSF*LLRN | 43 | kallikrein hK5 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| MEROPS | RSFL*LRNP | 44 | cathepsin G | physiologically relevant | NONE | 15371558 | ||
| MEROPS | SFLL*RNPN | 45 | kallikrein-related peptidase 6 | physiologically relevant | NONE | 16885167 | ||
| PMAP | SFLL*RNPN | 45 | kallikrein hK6 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| MEROPS | FLLR*NPND | 46 | chymotrypsin A (cattle-type) | not physiologically relevant | N-terminal sequencing | 8947506 | ||
| MEROPS | FLLR*NPND | 46 | thrombocytin | not physiologically relevant | NONE | 10908720 | ||
| MEROPS | FLLR*NPND | 46 | kallikrein-related peptidase 14 | physiologically relevant | NONE | 16885167 | ||
| MEROPS | FLLR*NPND | 46 | tryptase alpha | physiologically relevant | NONE | 9020112 | ||
| MEROPS | FLLR*NPND | 46 | platelet-aggregating venom peptidase | physiologically relevant | NONE | NONE | ||
| MEROPS | FLLR*NPND | 46 | kallikrein-related peptidase 6 | physiologically relevant | NONE | 16885167 | ||
| PMAP | FLLR*NPND | 46 | tryptase alpha | This entry is based on an experiment | Mass spectrometry | 9020112 | ||
| PMAP | FLLR*NPND | 46 | kallikrein hK14 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| PMAP | FLLR*NPND | 46 | kallikrein hK6 | This entry is based on an experiment | Mass spectrometry | 16885167 | ||
| HPRD | LLRN*PNDK | 47 | 10978167 | |||||
| HPRD | LRNP*NDKY | 48 | Proteinase 3 | 10978167 | ||||
| MEROPS | LRNP*NDKY | 48 | myeloblastin | physiologically relevant | NONE | 10978167 | ||
| MEROPS | PNDK*YEPF | 51 | tryptase alpha | physiologically relevant | NONE | 9020112 | ||
| PMAP | PNDK*YEPF | 51 | tryptase alpha | This entry is based on an experiment | Mass spectrometry | 9020112 | ||
| HPRD | KYEP*FWED | 54 | Proteinase 3 | 10978167 | ||||
| MEROPS | KYEP*FWED | 54 | myeloblastin | physiologically relevant | NONE | 10978167 | ||
| HPRD | YEPF*WEDE | 55 | Cathepsin G | 10978167 | ||||
| MEROPS | YEPF*WEDE | 55 | cathepsin G | physiologically relevant | NONE | 10978167 | ||
| HPRD | LTEY*RLVS | 69 | Cathepsin G | 10978167 | ||||
| MEROPS | LTEY*RLVS | 69 | cathepsin G | physiologically relevant | NONE | 10978167 | ||
| HPRD | TEYR*LVSI | 70 | Plasminogen | 10978167 | ||||
| MEROPS | TEYR*LVSI | 70 | trypsin 1 | not physiologically relevant | NONE | 10978167 | ||
| MEROPS | TEYR*LVSI | 70 | plasmin | physiologically relevant | NONE | 10978167 | ||
| HPRD | YRLV*SINK | 72 | Elastase, leukocyte; Proteinase 3; | 10978167 | ||||
| MEROPS | YRLV*SINK | 72 | elastase-2 | physiologically relevant | NONE | 10978167 | ||
| MEROPS | YRLV*SINK | 72 | myeloblastin | physiologically relevant | NONE | 10978167 | ||
| MEROPS | LVSI*NKSS | 74 | elastase-2 | physiologically relevant | NONE | 9058715 | ||
| HPRD | SINK*SSPL | 76 | Plasminogen; Calpain, large polypeptide L1; | 10978167 | ||||
| MEROPS | SINK*SSPL | 76 | calpain-1 | not physiologically relevant | NONE | 10978167 | ||
| MEROPS | SINK*SSPL | 76 | plasmin | physiologically relevant | NONE | 10978167 | ||
| HPRD | PLQK*QLPA | 82 | 10978167 | |||||
| MEROPS | PLQK*QLPA | 82 | trypsin 1 | not physiologically relevant | NONE | 10978167 | ||
| MEROPS | PLQK*QLPA | 82 | plasmin | physiologically relevant | NONE | 15371558 | ||
| HPRD | QLPA*FISE | 86 | Elastase, leukocyte | 10978167 | ||||
| MEROPS | QLPA*FISE | 86 | elastase-2 | physiologically relevant | NONE | 10978167 | ||
| HPRD | SEDA*SGYL | 92 | Proteinase 3 | 10978167 | ||||
| MEROPS | SEDA*SGYL | 92 | myeloblastin | physiologically relevant | NONE | 10978167 | ||
| PAPER | No_information | ADAM17 | 14982936 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |