UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P25095
Entry Name

AGTRA_RAT
Protein Name

Type-1A angiotensin II receptor
Primary Gene Name

Agtr1
Organism

Rattus norvegicus (Rat)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name angiotensin II type 1 receptor
Cell Type
Substrate Description receptor for angiotensin II.
Substrate Function Category blood and homoeostasis
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease vasoconstriction - cardiovascular system
Short Summary of Papers AT1R is subject to RIP (regulated intramembrane proteolysis) after ectodomain shedding, and the cytoplasmic domains are then transported to the cell nucleus
Cleavage Information ZNo-Human:
PMID 20080964



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		1 25
Transmembrane
 		26 55
Transmembrane
 		62 89
Extracellular
 		90 98
Transmembrane
 		99 125
Transmembrane
 		142 165
Extracellular
 		166 190
Transmembrane
 		191 216
Transmembrane
 		240 268
Extracellular
 		269 278
Transmembrane
 		279 304



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information metalloprotease 20080964   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA