UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P24530
Entry Name

EDNRB_HUMAN
Protein Name

Endothelin receptor type B
Primary Gene Name

EDNRB
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name endothelin B receptor
Cell Type
Substrate Description G protein-coupled receptor. receptor for endothelin 1, 2, and 3.
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease cell receptor (GPCR)
Short Summary of Papers the multispanning membrane protein ETB receptor is cleaved by a metalloprotease, while the functional activity and overall structure are still retained.
Cleavage Information NONE
PMID 12226103



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		27 101
Transmembrane
 		102 126
Transmembrane
 		138 163
Extracellular
 		164 175
Transmembrane
 		176 197
Transmembrane
 		219 243
Extracellular
 		244 271
Transmembrane
 		272 296
Transmembrane
 		325 350
Extracellular
 		351 362
Transmembrane
 		363 389



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
HPRD SLAR*SLAP 64 12226103   
HPRD SLAR*SLAP 64 12226103   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836