UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P24071
Entry Name

FCAR_HUMAN
Protein Name

Immunoglobulin alpha Fc receptor
Primary Gene Name

FCAR
Organism

Homo sapiens (Human)
Molecular Function

Receptor
IgA-binding protein
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name FcαR (CD89)
Cell Type
Substrate Description binds to the Fc region of immunoglobulins alpha
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM10, ADAM17
Shedding-related Disease cell receptor
Short Summary of Papers soluble forms of FcαR (sFcαR) are found in human serum, and are suggested via proteolytic shedding by ADAM10/ADAM17.
Cleavage Information NONE
PMID 20059578



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		22 227
Transmembrane
 		228 246



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM10,ADAM17 20059578   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 17081049
locate 17986452