UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P23515
Entry Name

OMGP_HUMAN
Protein Name

Oligodendrocyte-myelin glycoprotein
Primary Gene Name

OMG
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name oligodendrocyte myelin glycoprotein (OMGP)
Cell Type mouse antigen-specific T cell lines, human spinal fluid
Substrate Description
Substrate Function Category
Substrate Function Subtype
Sheddase Unknown
Shedding-related Disease multiple sclerosis, acute disseminated encephalomyelitis and psychosis
Short Summary of Papers soluble OMGP is found in serum of patients with multiple sclerosis, acute disseminated encephalomyelitis and psychosis; OMGP is an autoantigen of inflammatory CNS disorders
Cleavage Information
PMID 33256847



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS GILC*ICPL 24 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 3283151   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Bronchoalveolar lavage fluid 16497942
Sys-BodyFluid Cerebrospinal fluid 17853512
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Cerebrospinal fluid 15582749
Sys-BodyFluid Plasma/Serum 16047309
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 16083276