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| UniProt ID |
P23470 |
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| Entry Name |
PTPRG_HUMAN |
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| Protein Name |
Receptor-type tyrosine-protein phosphatase gamma |
|
| Primary Gene Name |
PTPRG |
|
| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Hydrolase |
|
| Membrane Location |
Membrane |
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| Substrate Name | Receptor-type tyrosine-protein phosphatase gamma (PTPRG) | |
| Cell Type | ||
| Substrate Description | protein tyrosine phosphatase (PTP) family. possesses tyrosine phosphatase activity. | |
| Substrate Function Category | enzyme;disease | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | receptor-type PTPases;hepatocyte damage | |
| Short Summary of Papers | the shed sPTPRG represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage. | |
| Cleavage Information | NONE | |
| PMID | 25775014 |
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Start | End |
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20 | 736 |
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737 | 762 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| ASCENT | VCFP*ALTE | 28 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | LTEG*YVGA | 33 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| PAPER | No_information | metalloprotease | 25775014 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| PAPER | platelet | 20962327 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 16083276 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |