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|---|---|---|
| UniProt ID |
P23229 |
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| Entry Name |
ITA6_HUMAN |
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| Protein Name |
Integrin alpha-6 |
|
| Primary Gene Name |
ITGA6 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
|
| Membrane Location |
Cell membrane |
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| Substrate Name | integrin alpha-6 | |
| Cell Type | ||
| Substrate Description | integrin alpha-6/beta-1 is a receptor for laminin; cell adhesion and migration | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | ||
| Sheddase | urokinase-type plasminogen activator | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | cleavage of the alpha6 integrin extracellular domain is involved in tumor cell invasion and migration on laminin | |
| Cleavage Information | NONE | |
| PMID | 17303120 |
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Start | End |
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24 | 1050 |
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1051 | 1076 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | LGAA*FNLD | 23 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2542022 | ||
| MEROPS | PSSR*RRVN | 633 | urokinase-type plasminogen activator | physiologically relevant | NONE | 17303120 | ||
| MEROPS | RKKR*EITE | 941 | PCSK7 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*EITE | 941 | PCSK5 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*EITE | 941 | PCSK6 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*EITE | 941 | PCSK2 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*EITE | 941 | PCSK4 peptidase | not physiologically relevant | consensus sequence | 18505722 | ||
| MEROPS | RKKR*EITE | 941 | furin | physiologically relevant | consensus sequence | 8760366 | ||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |