UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P22897
Entry Name

MRC1_HUMAN
Protein Name

Macrophage mannose receptor 1
Primary Gene Name

MRC1
Organism

Homo sapiens (Human)
Molecular Function

Host cell receptor for virus entry
Receptor
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name mannose receptor (MR)
Cell Type
Substrate Description endocytosis of glycoproteins by macrophages
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase metalloprotease
Shedding-related Disease cell receptor
Short Summary of Papers the shed soluble MR (sMR) maintained its ability to mannosylated ligand, might plays a role in the transport of mannosylated proteins from the site of inflammation to other parts of the body
Cleavage Information NONE
PMID 10545481 9722572



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		19 1389
Transmembrane
 		1390 1410



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 10545481   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(ovarian cancer) 22623176