UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P22303
Entry Name

ACES_HUMAN
Protein Name

Acetylcholinesterase
Primary Gene Name

ACHE
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Blood group antigen
Serine esterase
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name acetylcholinesterase (AChE)
Cell Type
Substrate Description terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype
Sheddase ADAM
Shedding-related Disease neurotransmitter
Short Summary of Papers metalloproteinase might be involved in the shedding of membrane-bound protein—acetylcholinesterase (AChE), and the shedding is stimulated by cholinergic agonists.
Cleavage Information GPI-anchor
PMID 21214569



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS GVGA*EGRE unknown peptidase physiologically relevant Mass spectroscopy 26796116   
PAPER No_information ADAM 21214569   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA