UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P22223
Entry Name

CADH3_HUMAN
Protein Name

Cadherin-3
Primary Gene Name

CDH3
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name P-cadherin
Cell Type
Substrate Description calcium-dependent cell adhesion proteins,placental(found in the placenta)
Substrate Function Category disease
Substrate Function Subtype
Sheddase MMP1, MMP2
Shedding-related Disease cancer (tumor invasion)
Short Summary of Papers the shed soluble P-cadherin fragment is able to induce in vitro invasion of breast cancer cells
Cleavage Information NONE
PMID 19901964



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		108 654
Transmembrane
 		655 677



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS RHKR*DWVV 107 kallikrein-related peptidase 4 physiologically relevant consensus sequence 15389820   
PAPER RHKR*DWVV 107 UNKNOWN Mass spectrometry 33796845   
PAPER EVQR*LTVT 348 UNKNOWN Mass spectrometry 33796845   
PAPER EPVC*VYTA 460 UNKNOWN Mass spectrometry 33796845   
PAPER DPAG*WLAM 484 UNKNOWN Mass spectrometry 33796845   
PAPER No_information MMP1,MMP2 19901964   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Amniotic fluid 17495049
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colorectal cancer 24418523
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(Liver metastasis in colorectal cancer) 23443137