UniProt Summary
UniProt ID

P21926

Entry Name

CD9_HUMAN

Protein Name

CD9 antigen

Primary Gene Name

CD9

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name CD9
Cell Type
Substrate Description platelet activation and aggregation.cell adhesion, cell motility and tumor metastasis
Substrate Function Category disease
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cancer (leukaemia)
Short Summary of Papers shedding of CD9 antigen by leukemic cells may enable the clinical monitoring of residual leukemic cell burden
Cleavage Information NONE
PMID 1390240 8180600



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Transmembrane
13 33
Extracellular
34 55
Transmembrane
56 76
Transmembrane
88 111
Extracellular
112 195
Transmembrane
196 221



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS M*PVKG 1 unknown peptidase physiologically relevant N-terminal sequencing 2358073   
PAPER No_information (unknown) 1390240    8180600   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER platelet 20962327
SPD 22728825
Sys-BodyFluid Milk 16502470
Sys-BodyFluid Seminal Fluid 16709260
Sys-BodyFluid Saliva 17614365
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18793429
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(pancreatic cancer) 16215274
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(colorectal cancer 24418523
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Lung adenocarcinoma) 22985211
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
HCSD cancer(non small cell lung cancer) 19655816
HCSD cancer(colorectal cancer) 25216327