UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P21802
Entry Name

FGFR2_HUMAN
Protein Name

Fibroblast growth factor receptor 2
Primary Gene Name

FGFR2
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Transferase
Kinase
Receptor
Heparin-binding
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name FGFR2iiib
Cell Type
Substrate Description FGFR signaling, various signals in cell proliferation, differentiation and migration
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth factor (FGFR)
Sheddase ADAM9
Shedding-related Disease growth factor (FGFR)
Short Summary of Papers the shed soluble ectodomain of FGFR2iiib has been reported to function in a dominant-negative fashion and disrupt FGF signaling
Cleavage Information NONE
PMID 16230393



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		22 377
Transmembrane
 		378 398



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM9 16230393   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Cerebrospinal fluid 18052119
HCSD cancer (gastric cancer) 23161554
locate 17986452