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| UniProt ID |
P21589 |
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| Entry Name |
5NTD_HUMAN |
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| Protein Name |
5'-nucleotidase |
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| Primary Gene Name |
NT5E |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Hydrolase |
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| Membrane Location |
Cell membrane |
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| Substrate Name | CD73 | |
| Cell Type | ||
| Substrate Description | hydrolyzes extracellular nucleotides into membrane permeable nucleosides. | |
| Substrate Function Category | enzyme | |
| Substrate Function Subtype | ||
| Sheddase | (unknown) | |
| Shedding-related Disease | nucleotidase | |
| Short Summary of Papers | CD73 molecules on lymphocytes are shed from the cell surface, the ligand- induced shedding of lymphocyte CD73 represents an important and novel means of controlling lymphocyte– EC interactions. | |
| Cleavage Information | GPI-anchor | |
| PMID | 9015312 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | IKFS*TGSH | 549 | glycosylphosphatidylinositol:protein transamidase | physiologically relevant | N-terminal sequencing | 2129526 | ||
| PAPER | No_information | (unknown) | 9015312 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer) | 24681409 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(lung adenocarcinoma) | 22896658 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |