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| UniProt ID |
P21583 |
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| Entry Name |
SCF_HUMAN |
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| Protein Name |
Kit ligand |
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| Primary Gene Name |
KITLG |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Growth factor |
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| Membrane Location |
Secreted |
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| Substrate Name | Kit ligand, stem cell factor (SCF) | |
| Cell Type | ||
| Substrate Description | Kit Signaling in cell survival and proliferation, development, hematopoiesis | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (Kit) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | growth factor (kit) | |
| Short Summary of Papers | shedding of Kit ligand (Kitl), produce soluble form of growth factor | |
| Cleavage Information | NONE | |
| PMID | 17344430 |
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Start | End |
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26 | 214 |
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215 | 237 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | VSST*LSPE | 168 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | TKPF*MLPP | 183 | Chymase 1 | 10224464 | ||||
| MEROPS | TKPF*MLPP | 183 | chymase (Homo sapiens-type) | physiologically relevant | NONE | 12815038 | ||
| PMAP | TKPF*MLPP | 183 | chymase | This entry is based on an experiment | N-terminal sequencing | 9256427 10224464 | ||
| MEROPS | PVAA*SSLR | 190 | ADAM19 peptidase | not physiologically relevant | NONE | 12682046 | ||
| PAPER | No_information | ADAM17, MMP | Gel electrophoresis | 18239612 | ||||
| PMAP | No_information | NONE | This entry is based on an experiment | Gel electrophoresis | 1378327 | |||
| PMAP | No_information | NONE | This entry is based on an experiment | Gel electrophoresis | 1378327 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Plasma/Serum | 15822942 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| locate | 17986452 | ||