UniProt Summary
UniProt ID

P20916

Entry Name

MAG_HUMAN

Protein Name

Myelin-associated glycoprotein

Primary Gene Name

MAG

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name Myelin-associated glycoprotein (MAG)
Cell Type
Substrate Description neural development
Substrate Function Category central nervous system (neuron)
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase MMP7
Shedding-related Disease cell adhesion molecule
Short Summary of Papers proteolysis of transmembrane MAG release derivative myelin associated glycoprotein (dMAG) and can inhibit axonal growth
Cleavage Information NONE
PMID 18063113



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
20 516
Transmembrane
517 536



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS GYAS*MDVK 233 matrix metallopeptidase-7 physiologically relevant NONE 18063113   
PMAP GYAS*MDVK 233 matrix metallopeptidase-7 This entry is based on an experiment N-terminal sequencing 18063113   
MEROPS GAHR*LMWA 508 matrix metallopeptidase-7 physiologically relevant NONE 18063113   
PMAP GAHR*LMWA 508 matrix metallopeptidase-7 This entry is based on an experiment N-terminal sequencing 18063113   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 12917320
Sys-BodyFluid Plasma/Serum 16083276
Sys-BodyFluid Plasma/Serum 14718574