UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P20827
Entry Name

EFNA1_HUMAN
Protein Name

Ephrin-A1
Primary Gene Name

EFNA1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Ephrin-A1
Cell Type
Substrate Description cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development.
Substrate Function Category disease
Substrate Function Subtype
Sheddase ADAM12
Shedding-related Disease cancer (lung metastasis)
Short Summary of Papers released of soluble ephrin-A1 in the serum deteriorated the EphA1/ephrin-A1-mediated cell adhesion, causing lung hyperpermeability that facilitated tumor cell entry into the lungs
Cleavage Information GPI-anchor
PMID 23686306



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS LAAA*DRHT 18 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER No_information ADAM12 23686306   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Urine 16281181
Sys-BodyFluid Urine 16948836
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Head and neck squamous cell carcinoma) 23665456
HCSD cancer(colon tumor) 23684732
HCSD cancer(pancreatic cancer) 21625447
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
locate 17986452