UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P20693
Entry Name

FCER2_MOUSE
Protein Name

Low affinity immunoglobulin epsilon Fc receptor
Primary Gene Name

Fcer2
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
IgE-binding protein
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD23 (Low affinity IgE Fc receptor)
Cell Type B cell lines
Substrate Description immunoglobulin signaling and immune response
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; receptor (immunoglobulin)
Sheddase ADAM8, ADAM15, ADAM10, ADAM28, ADAM33
Shedding-related Disease cell receptor
Short Summary of Papers proteolytic release of soluble CD23, result in up-regulation of IgE production and the induction of inflammatory cytokines
Cleavage Information NONE
PMID 19049889 26538900



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Transmembrane
 		24 49
Extracellular
 		50 331



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER QLAQ*KSQV 83 metalloprotease,ADAM8 16542157   
PAPER LAQK*SQVV 84 metalloprotease,ADAM8 16542157   
PAPER No_information ADAM10 17072319   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825