UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P20138
Entry Name

CD33_HUMAN
Protein Name

Myeloid cell surface antigen CD33
Primary Gene Name

CD33
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name CD33
Cell Type
Substrate Description putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells
Substrate Function Category disease
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cancer (AML)
Short Summary of Papers CD33 can be shed and was found in bone marrow plasma of patients with AML. the shed sCD33 may be a useful marker for certain subsets of AML and potential therapeutic target.
Cleavage Information NONE
PMID 24674885 20362641 16828866



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		18 259
Transmembrane
 		260 282



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 24674885    20362641    16828866   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Urine 16948836