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| UniProt ID |
P19941 |
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| Entry Name |
GHR_RABIT |
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| Protein Name |
Growth hormone receptor |
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| Primary Gene Name |
GHR |
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| Organism |
Oryctolagus cuniculus (Rabbit) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | GHR | |
| Cell Type | lymphocytes IM-9, CHO | |
| Substrate Description | growth hormone (GH) signaling | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth hormone receptor | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | growth hormone receptor | |
| Short Summary of Papers | circulating GH-binding protein (GHBP) generated by shedding of GHR receptor's ligand-binding extracellular domain. GHBP may function as either a potentiator (by delaying GH clearance) or an inhibitor (by GH sequestration) | |
| Cleavage Information | NONE | |
| PMID | 11309389 |
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Start | End |
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19 | 264 |
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265 | 288 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | QMSP*FTCE | 256 | ADAM17 peptidase | physiologically relevant | NONE | NONE | ||
| PAPER | QMSP*FTCE | 256 | ADAM17 | N-terminal sequencing | 12403792 | |||
| PMAP | QMSP*FTCE | 256 | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | N-terminal sequencing | 12403792 15743767 | ||
| PMAP | No_information | presenilin 1 | This_entry_is_based_on_an_experiment. | Others | 15743767 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| NO_DATA | NO_DATA | NO_DATA | |