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| UniProt ID |
P19438 |
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| Entry Name |
TNR1A_HUMAN |
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| Protein Name |
Tumor necrosis factor receptor superfamily member 1A |
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| Primary Gene Name |
TNFRSF1A |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | TNFRI | |
| Cell Type | endothelial cell, monocytes, lymphocytes, neutrophils | |
| Substrate Description | Leukocyte Recruitment, Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cytokine receptor | |
| Sheddase | ADAM17, NE(neutrophil elastase) | |
| Shedding-related Disease | cytokine receptor | |
| Short Summary of Papers | receptor down-regulation,soluble TNF antagonist | |
| Cleavage Information | NONE | |
| PMID | 16565325 |
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Start | End |
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30 | 211 |
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212 | 232 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | GELE*GTTT | 260 | Caspase 7 | 11755217 | ||||
| PMAP | GELE*GTTT | 260 | caspase-7 | This entry is based on an experiment | 11755217 | |||
| PMAP | No_information | ADAM17 peptidase | This entry is based on an experiment | 10925303 | ||||
| PMAP | No_information | aminopeptidase PILS | This entry is based on an experiment | 12748171 | ||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Nipple aspiration fluid | 12889602 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | non-small cell lung cancer | 21262398 | |