UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P19320
Entry Name

VCAM1_HUMAN
Protein Name

Vascular cell adhesion protein 1
Primary Gene Name

VCAM1
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name VCAM-1
Cell Type endothelial cell
Substrate Description Leukocyte Recruitment, Firm adhesion and locomotion to the endothelial cell junction
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cell adhesion molecule
Sheddase NE(neutrophil elastase), ADAM17
Shedding-related Disease cell adhesion molecule
Short Summary of Papers de-adhesion,soluble adhesion antagonist
Cleavage Information NONE
PMID 16565325 15949468



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 698
Transmembrane
 		699 720



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS ASQA*FKIE 24 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
PAPER No_information metalloprotease 7529789   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER platelet 20962327
SPD 22728825
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 17022648
Sys-BodyFluid Urine 15048996
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 18793429
Sys-BodyFluid Plasma/Serum 18795103
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 16944932
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Plasma/Serum 14718574
Sys-BodyFluid Urine 16281181
HCSD cancer(colorectal cancer 22408128
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646
locate 17986452