UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P19022
Entry Name

CADH2_HUMAN
Protein Name

Cadherin-2
Primary Gene Name

CDH2
Organism

Homo sapiens (Human)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name N-cadherin
Cell Type mouse neuroblastoma N2a cells, human neuroglioma H4 cells
Substrate Description cell migration; neurite outgrowth
Substrate Function Category central nervous system (neuron);disease
Substrate Function Subtype Central nervous system (CNS) pathology; cell adhesion molecules
Sheddase ADAM10
Shedding-related Disease cell adhesion molecule; cancer (prostate)
Short Summary of Papers release of the extracellular domain, for the regulation of cell adhesion, cell migration. decreased neuronal cell adhesion, increased neurite outgrowth
Cleavage Information NONE
PMID 19049889 15692570 18951988 16998833



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		160 724
Transmembrane
 		725 745



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
ASCENT SVEA*SGEI 25 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AVKL*SLKP 121 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AVKL*SLKP 121 UNKNOWN subtiligase-based N-terminal sequencing
MEROPS RQKR*DWVI 159 kallikrein-related peptidase 4 physiologically relevant consensus sequence 15389820   
PAPER RQKR*DWVI 159 UNKNOWN Mass spectrometry 33796845   
PAPER PSPN*MFTI 319 UNKNOWN Mass spectrometry 33796845   
ASCENT FTAM*TFYG 385 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT FTAM*TFYG 385 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT FTAM*TFYG 385 UNKNOWN subtiligase-based N-terminal sequencing
ASCENT TAMT*FYGE 386 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT TAMT*FYGE 386 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT TAMT*FYGE 386 UNKNOWN subtiligase-based N-terminal sequencing
ASCENT AMTF*YGEV 387 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT MFVL*TVAA 460 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT MFVL*TVAA 460 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT MFVL*TVAA 460 UNKNOWN subtiligase-based N-terminal sequencing
ASCENT FVLT*VAAE 461 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT VLTV*AAEN 462 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT VLTV*AAEN 462 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT LTVA*AENQ 463 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT LTVA*AENQ 463 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT VSVT*VIDV 487 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AGTM*LTTF 515 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT GTML*TTFT 516 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT TMLT*TFTA 517 UNKNOWN subtiligase-based N-terminal sequencing
ASCENT MLTT*FTAQ 518 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT LTTF*TAQD 519 UNKNOWN subtiligase-based N-terminal sequencing
ASCENT QNIR*YTKL 533 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT YTKL*SDPA 537 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AGPF*AFDL 637 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
ASCENT AGPF*AFDL 637 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PAPER No_information ADAM10 Gel electrophoresis 15692570   
PMAP No_information matrix metallopeptidase This entry is based on an experiment 14960160    12775583   
PMAP No_information gingipain R1 This entry is based on an experiment Gel electrophoresis 16988242   
PMAP No_information gingipain K This entry is based on an experiment Gel electrophoresis 16988242   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER cancer(ovary) 18560578
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Cerebrospinal fluid 17853512
Sys-BodyFluid Cerebrospinal fluid 18052119
Sys-BodyFluid Cerebrospinal fluid 15582749
Sys-BodyFluid Cerebrospinal fluid 14998169
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16281181
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 16104056
HCSD cancer (gastric cancer) 23161554
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal cancer 24418523
HCSD cancer(urothelial carcinoma) 23591195
HCSD cancer(glioblastoma multiforme) 21574646
HCSD cancer(breast cancer) 24505115
HCSD cancer(non small cell lung cancer) 19655816