UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P18828
Entry Name

SDC1_MOUSE
Protein Name

Syndecan-1
Primary Gene Name

Sdc1
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Secreted
Membrane



Biological Literature Report of Shedding
Substrate Name Syndecan-1
Cell Type HT1080 fibrosarcoma cells
Substrate Description cell migration, cell morphogenesis
Substrate Function Category cell surface structure
Substrate Function Subtype cell adhesion molecule
Sheddase MT-MMP1
Shedding-related Disease proteoglycan
Short Summary of Papers cleavage of syndecan-1 stimulates cell migration, regulate syndecans role in tissue morphogenesis, migratory and invasive behaviors
Cleavage Information NONE
PMID 12904296
Substrate Name Syndecan-1
Cell Type tumor cells
Substrate Description cancer cell invasion and proliferation
Substrate Function Category disease
Substrate Function Subtype Disease: Cancers (invasion)
Sheddase MMP7, MMP9
Shedding-related Disease cancer (invasion)
Short Summary of Papers activated Sdc-1 shedding may be involved in tumour cell proliferation and invasion
Cleavage Information NONE
PMID 25321193



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		23 255
Transmembrane
 		256 276



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS GSGD*DSDN 39 thermolysin physiologically relevant NONE 16926147   
PMAP GSGD*DSDN 39 neutral protease Npr599 This_entry_is_based_on_an_experiment. Mass spectrometry 16926147   
MEROPS SGSG*TGAL 48 immune inhibitor A peptidase (Bacillus sp.) physiologically relevant NONE 16926147   
PMAP SGSG*TGAL 48 immune inhibitor A This_entry_is_based_on_an_experiment. Mass spectrometry 16926147   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA