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| UniProt ID |
P18827 |
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| Entry Name |
SDC1_HUMAN |
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| Protein Name |
Syndecan-1 |
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| Primary Gene Name |
SDC1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | Syndecan-1 | |
| Cell Type | HT1080 fibrosarcoma cells | |
| Substrate Description | cell migration, cell morphogenesis | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell adhesion molecule | |
| Sheddase | MT-MMP1 | |
| Shedding-related Disease | proteoglycan | |
| Short Summary of Papers | cleavage of syndecan-1 stimulates cell migration, regulate syndecans role in tissue morphogenesis, migratory and invasive behaviors | |
| Cleavage Information | NONE | |
| PMID | 12904296 |
| Substrate Name | Syndecan-1 | |
| Cell Type | tumor cells | |
| Substrate Description | cancer cell invasion and proliferation | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (invasion) | |
| Sheddase | MMP7, MMP9 | |
| Shedding-related Disease | cancer (invasion) | |
| Short Summary of Papers | activated Sdc-1 shedding may be involved in tumour cell proliferation and invasion | |
| Cleavage Information | NONE | |
| PMID | 25321193 |
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Start | End |
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23 | 254 |
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255 | 275 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| HPRD | EPTG*LEAT | 82 | Matrix metalloproteinase 14 | 12904296 | ||||
| HPRD | EPTG*LEAT | 82 | Matrix metalloproteinase 14 | 12904296 | ||||
| MEROPS | EPTG*LEAT | 82 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 15466200 | ||
| ASCENT | ATAA*STST | 88 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| ASCENT | ATAA*STST | 88 | UNKNOWN | subtiligase-based N-terminal sequencing | ||||
| MEROPS | LPAG*EGPK | 96 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | GPKE*GEAV | 101 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | PKEG*EAVV | 102 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | EGEA*VVLP | 104 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VVLP*EVEP | 108 | UNKNOWN | Mass spectrometry | 33796845 | |||
| MEROPS | DFTF*ETSG | 213 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| MEROPS | FTFE*TSGE | 214 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| ASCENT | FETS*GENT | 216 | UNKNOWN | subtiligase-based N-terminal sequencing | 33536314 | |||
| MEROPS | FETS*GENT | 216 | meprin beta subunit | not physiologically relevant | Mass spectroscopy | 21693781 | ||
| PAPER | ATGA*SQGL | 242 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | ASQG*LLDR | 245 | Matrix metalloproteinase 14 | 12904296 | ||||
| HPRD | ASQG*LLDR | 245 | Matrix metalloproteinase 14 | 12904296 | ||||
| MEROPS | ASQG*LLDR | 245 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 12904296 | ||
| PAPER | ASQG*LLDR | 245 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PMAP | ASQG*LLDR | 245 | matrix metallopeptidase-1 | This entry is based on an experiment | 12904296 | |||
| PMAP | ASQG*LLDR | 245 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Gel electrophoresis | 12904296 | ||
| PMAP | ASQG*LLDR | 245 | membrane-type matrix metallopeptidase-1 | This entry is based on an experiment | Gel electrophoresis | 12904296 | ||
| PAPER | GVIA*GGLV | 258 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GLVG*LIFA | 263 | UNKNOWN | Mass spectrometry | 33796845 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16948836 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(pancreatic cancer) | 16215274 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |