UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P18337
Entry Name

LYAM1_MOUSE
Protein Name

L-selectin
Primary Gene Name

Sell
Organism

Mus musculus (Mouse)
Molecular Function

Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name L-selectin
Cell Type lymphocytes,monocytes,neutrophils
Substrate Description Leukocyte Recruitment - Tethering and rolling
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cell adhesion molecule
Sheddase ADAM17
Shedding-related Disease cell adhesion molecule
Short Summary of Papers de-adhesion, increase rolling velocity
Cleavage Information NONE
PMID 16565325 9812885



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		39 332
Transmembrane
 		333 355



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER TNRS*FSKI 322 ADAM17 16542157   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA