UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P18052
Entry Name

PTPRA_MOUSE
Protein Name

Receptor-type tyrosine-protein phosphatase alpha
Primary Gene Name

Ptpra
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Protein phosphatase
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Receptor-type tyrosine-protein phosphatase alpha (PTPĪ±)
Cell Type
Substrate Description protein tyrosine phosphatase (PTP) family. involved in the regulation of tyrosine kinases like the Src kinase and the insulin receptor.
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease receptor-type PTPases
Short Summary of Papers extracellular proteolytic processing is a novel mechanism for PTPĪ± regulation, and may induce degradation of the phosphatase.
Cleavage Information ZNo-Human:
PMID 18713734



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		20 142
Transmembrane
 		143 166



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 18713734   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA