UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P17948
Entry Name

VGFR1_HUMAN
Protein Name

Vascular endothelial growth factor receptor 1
Primary Gene Name

FLT1
Organism

Homo sapiens (Human)
Molecular Function

Tyrosine-protein kinase
Developmental protein
Transferase
Kinase
Receptor
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name VEGFR-1/FLT1
Cell Type
Substrate Description Tyrosine-protein kinase, cell-surface receptor for VEGFA, VEGFB and PGF
Substrate Function Category angiogenesis
Substrate Function Subtype
Sheddase ADAM
Shedding-related Disease cell receptor
Short Summary of Papers VEGFR-1 undergo cleavage by ADAM and γ-secretase (regulated intramembrane proteolysis) sequentially, the shed sVEGFR-1 may antagonize VEGF receptor signaling by acting as a dominant-negative form and/or forming a nonsignaling dimerizing complex with VEGF receptors.
Cleavage Information NONE
PMID 19276374



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		27 758
Transmembrane
 		759 780



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM 19276374   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 16104056
Sys-BodyFluid Amniotic fluid 17495049
Sys-BodyFluid Plasma/Serum 16878292
Sys-BodyFluid Plasma/Serum 17553692
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(Liver metastasis in colorectal cancer) 23443137