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|---|---|---|
| UniProt ID |
P17813 |
|
| Entry Name |
EGLN_HUMAN |
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| Protein Name |
Endoglin |
|
| Primary Gene Name |
ENG |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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|---|
| Substrate Name | endoglin (CD105) | |
| Cell Type | ||
| Substrate Description | TGF-beta coreceptor. TGF-beta/BMP signaling cascade. regulation of angiogenesis | |
| Substrate Function Category | angiogenesis | |
| Substrate Function Subtype | ||
| Sheddase | MT1-MMP | |
| Shedding-related Disease | cell receptor | |
| Short Summary of Papers | MMP-14 mediates endoglin shedding, and may regulate the angiogenic potential of endothelial cells in the (colorectal) tumor microenvironment. | |
| Cleavage Information | NONE | |
| PMID | 20424116 22296769 |
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|---|---|---|
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Start | End |
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26 | 586 |
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587 | 611 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | TSLA*ETVH | 25 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 1692830 | ||
| PAPER | TSKG*LVLP | 586 | MT1-MMP | mutagenesis | 20424116 22296769 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |