UniProt Summary
UniProt ID

P16871

Entry Name

IL7RA_HUMAN

Protein Name

Interleukin-7 receptor subunit alpha

Primary Gene Name

IL7R

Organism

Homo sapiens (Human)

Molecular Function

Receptor

Membrane Location

Secreted
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name IL-7 receptor alpha (CD127)
Cell Type
Substrate Description receptor for interleukin-7
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease cytokine receptor
Short Summary of Papers IL-7 decreases IL-7 receptor α (CD127) expression and induces the shedding of CD127 by human CD8+ T cells
Cleavage Information NONE
PMID 17956896



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
21 239
Transmembrane
240 264



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown) 17956896   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
HCSD cancer(23 cancer cell lines) 20124221