UniProt Summary
UniProt ID

P16581

Entry Name

LYAM2_HUMAN

Protein Name

E-selectin

Primary Gene Name

SELE

Organism

Homo sapiens (Human)

Molecular Function

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name E-selectin
Cell Type endothelial cells
Substrate Description Leukocyte Recruitment, Tethering and rolling
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cell adhesion molecule
Sheddase unknown
Shedding-related Disease cell adhesion molecule
Short Summary of Papers de-adhesion,soluble adhesion antagonist
Cleavage Information NONE
PMID 16565325 9441802



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
22 556
Transmembrane
557 578



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS DCVE*IYIK 113 glutamyl peptidase I not physiologically relevant NONE 7536194   
MEROPS IKRE*KDVG 119 glutamyl peptidase I not physiologically relevant NONE 7536194   
MEROPS WNDE*RCSK 128 glutamyl peptidase I not physiologically relevant NONE 7536194   
PAPER No_information (unknown) not physiologically relevant NONE 9441802   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Plasma/Serum 14718574
locate 17986452