UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P16473
Entry Name

TSHR_HUMAN
Protein Name

Thyrotropin receptor
Primary Gene Name

TSHR
Organism

Homo sapiens (Human)
Molecular Function

Receptor
G-protein coupled receptor
Transducer
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name thyrotropin receptor (TSHR)
Cell Type
Substrate Description growth hormone (TSHR) signaling
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype growth hormone receptor
Sheddase ADAM17
Shedding-related Disease growth hormone receptor (TSHR)
Short Summary of Papers The shedding of the ectodomain result in enhanced constitutive activity of the receptor, regulated by thyrotropin.
Cleavage Information NONE
PMID 18074395



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		21 413
Transmembrane
 		414 441
Transmembrane
 		451 473
Extracellular
 		474 494
Transmembrane
 		495 517
Transmembrane
 		538 560
Extracellular
 		561 580
Transmembrane
 		581 602
Transmembrane
 		626 649
Extracellular
 		650 660
Transmembrane
 		661 682



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information ADAM17 18074395   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 14718574