UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P16444
Entry Name

DPEP1_HUMAN
Protein Name

Dipeptidase 1
Primary Gene Name

DPEP1
Organism

Homo sapiens (Human)
Molecular Function

Hydrolase
Protease
Dipeptidase
Metalloprotease
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Dipeptidase 1(RDPase)
Cell Type
Substrate Description hydrolyzes a wide range of dipeptides. implicated in the renal metabolism of glutathione and its conjugates.
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase phospholipase C
Shedding-related Disease peptidase
Short Summary of Papers Nitric oxide server as an inhibitory regulator of the shedding and release of the GPI-anchored RDPase in acute renal failure.
Cleavage Information NONE
PMID 11988094



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS VCTA*DFFR 16 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 15340161   
MEROPS GYSS*GASS 385 glycosylphosphatidylinositol:protein transamidase physiologically relevant N-terminal sequencing 16959974   
PAPER No_information phospholipase C 11988094   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Saliva 18361515
Sys-BodyFluid Urine 11680902
Sys-BodyFluid Urine 16335936
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 17553692
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal cancer 22408128