UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P16422
Entry Name

EPCAM_HUMAN
Protein Name

Epithelial cell adhesion molecule
Primary Gene Name

EPCAM
Organism

Homo sapiens (Human)
Molecular Function

Tumor antigen
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name EPCAM
Cell Type
Substrate Description homophilic cell adhesion molecule that interferes with cadherin-mediated cell–cell contact
Substrate Function Category morphogenesis (epithelial cell proliferation)
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease cell adhesion molecule
Short Summary of Papers ectodomain shedding result in RIP (regulated intramembrane proteolysis) and transcriptional activation of target genes in cell proliferation
Cleavage Information NONE
PMID 19136966 24665393



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		24 265
Transmembrane
 		266 288



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER ATFA*AAQE 21 UNKNOWN Mass spectrometry 33796845   
MEROPS LGRR*AKPE 81 kallikrein-related peptidase 4 physiologically relevant consensus sequence 15389820   
PAPER DVAY*YFEK 214 UNKNOWN Mass spectrometry 33796845   
PAPER No_information ADAM17 19136966   
PAPER No_information serine protease 16232214   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
Sys-BodyFluid Urine 16948836
Sys-BodyFluid Plasma/Serum 16739989
HCSD cancer (gastric cancer) 23161554
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colon tumor) 23684732
HCSD cancer(colorectal cancer 22408128
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(colorectal cancer 24418523
HCSD cancer(head and neck squamous cell carcinoma) 22918226
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(gastric cancer) 22204653
HCSD cancer(lung cancer) 21186846
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
locate 17986452