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| UniProt ID |
P16284 |
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| Entry Name |
PECA1_HUMAN |
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| Protein Name |
Platelet endothelial cell adhesion molecule |
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| Primary Gene Name |
PECAM1 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Cell membrane |
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| Substrate Name | CD31 (PECAM-1) | |
| Cell Type | lymphocytes | |
| Substrate Description | ||
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: infection (HIV) | |
| Sheddase | metalloproteinases and caspases | |
| Shedding-related Disease | infection (HIV) | |
| Short Summary of Papers | shedding of PECAM-1 during HIV infection, contributing to enhanced transmigration of HIV-infected leukocytes | |
| Cleavage Information | NONE | |
| PMID | 16507710 |
| Substrate Name | CD31 (PECAM-1) | |
| Cell Type | endothelial cell, monocytes, lymphocytes, neutrophils | |
| Substrate Description | Leukocyte Recruitment, Cell-cell adhesion molecules involved in endothelial diapedesis | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cell adhesion molecule | |
| Sheddase | MMP/ADAM | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | shedding of PECAM-1 altered signaling in caspase activation,and destabilize EC junctions | |
| Cleavage Information | NONE | |
| PMID | 16565325 |
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Start | End |
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28 | 601 |
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602 | 620 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | SLEG*QENS | 27 | signal peptidase complex (animal) | physiologically relevant | Mass spectroscopy | 16038019 | ||
| MEROPS | HGNK*AVYS | 287 | lysyl endopeptidase (bacteria) | not physiologically relevant | Mass spectroscopy | NONE | ||
| MEROPS | RISK*VSSI | 313 | lysyl endopeptidase (bacteria) | not physiologically relevant | Mass spectroscopy | NONE | ||
| PMAP | No_information | matrix metallopeptidase-9 | This entry is based on an experiment | Others | 16409549 | |||
| PMAP | No_information | matrix metallopeptidase-7 | This entry is based on an experiment | Others | 16409549 | |||
| PMAP | No_information | gingipain R | This entry is based on an experiment | Gel electrophoresis | 15731036 | |||
| PMAP | No_information | gingipain K | This entry is based on an experiment | Gel electrophoresis | 15731036 | |||