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| UniProt ID |
P16144 |
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| Entry Name |
ITB4_HUMAN |
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| Protein Name |
Integrin beta-4 |
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| Primary Gene Name |
ITGB4 |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | Integrin beta-4 | |
| Cell Type | ||
| Substrate Description | integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | ||
| Sheddase | MMP9 | |
| Shedding-related Disease | epithelial erosion | |
| Short Summary of Papers | cleavage of the β4 integrin ectodomain by MMP9 lead to recurrent epithelial erosions during erosion formation | |
| Cleavage Information | NONE | |
| PMID | 21750188 |
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Start | End |
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28 | 710 |
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711 | 733 |
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|---|---|---|---|---|---|---|---|---|
| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | GTLA*NRCK | 27 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 2542022 | ||
| MEROPS | SDGL*KMDA | 444 | matrix metallopeptidase-7 | physiologically relevant | NONE | 9344615 | ||
| MEROPS | DELD*RSFT | 1109 | caspase-7 | physiologically relevant | mutation | 17178732 | ||
| MEROPS | DELD*RSFT | 1109 | caspase-3 | physiologically relevant | mutation | 17178732 | ||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Plasma/Serum | 16878292 | |
| Sys-BodyFluid | Plasma/Serum | 17081049 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |