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| UniProt ID |
P16070 |
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| Entry Name |
CD44_HUMAN |
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| Protein Name |
CD44 antigen |
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| Primary Gene Name |
CD44 |
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| Organism |
Homo sapiens (Human) |
|
| Molecular Function |
Receptor |
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| Membrane Location |
Cell membrane |
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| Substrate Name | CD44 | |
| Cell Type | endothelial cell, monocytes, lymphocytes, neutrophils | |
| Substrate Description | Leukocyte Recruitment, Firm adhesion and locomotion to the endothelial cell junction | |
| Substrate Function Category | Immune and Inflammation | |
| Substrate Function Subtype | Immune and Inflammation; cell adhesion molecule | |
| Sheddase | ADAM10, ADAM17, MT1MMP | |
| Shedding-related Disease | cell adhesion molecule | |
| Short Summary of Papers | de-adhesion,cell migration,transcriptional activation;dynamic regulation of the interaction between CD44 and the ECM during cell migration | |
| Cleavage Information | NONE | |
| PMID | 16565325 15197174 18951988 |
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Start | End |
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21 | 649 |
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650 | 670 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | LSLA*QIDL | 20 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | AFNS*TLPT | 58 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | QMEK*ALSI | 68 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | GFET*CRYG | 76 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | APPE*EDCT | 126 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | PPEE*DCTS | 127 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | PEED*CTSV | 128 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | NAFD*GPIT | 140 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | GEYR*TNPE | 162 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | GEYR*TNPE | 162 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | GEYR*TNPE | 162 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | GEYR*TNPE | 162 | Matrix metalloproteinase 1 | 11381077 | ||||
| MEROPS | GEYR*TNPE | 162 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 11381077 | ||
| PAPER | EDIY*PSNP | 169 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DIYP*SNPT | 170 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | YPSN*PTDD | 172 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | SNPT*DDDV | 174 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | NPTD*DDVS | 175 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | PTDD*DVSS | 176 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | TDDD*VSSG | 177 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DDVS*SGSS | 179 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | DVSS*GSSS | 180 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | VSSG*SSSE | 181 | UNKNOWN | Mass spectrometry | 33796845 | |||
| HPRD | SSER*SSTS | 186 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | SSER*SSTS | 186 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | SSER*SSTS | 186 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | SSER*SSTS | 186 | Matrix metalloproteinase 1 | 11381077 | ||||
| MEROPS | SSER*SSTS | 186 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 11381077 | ||
| HPRD | TSGG*YIFY | 192 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | TSGG*YIFY | 192 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | TSGG*YIFY | 192 | Matrix metalloproteinase 1 | 11381077 | ||||
| HPRD | TSGG*YIFY | 192 | Matrix metalloproteinase 1 | 11381077 | ||||
| MEROPS | TSGG*YIFY | 192 | membrane-type matrix metallopeptidase-1 | physiologically relevant | NONE | 11381077 | ||
| MEROPS | SLLA*LALI | 659 | presenilin 1 | physiologically relevant | NONE | 12223485 | ||
| PAPER | PDQF*MTAD | 724 | UNKNOWN | Mass spectrometry | 33796845 | |||
| PAPER | No_information | ADAM10, ADAM17 | 15197174 | |||||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| Sys-BodyFluid | Amniotic fluid | 17373841 | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Urine | 11680902 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 17553692 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| Sys-BodyFluid | Seminal Fluid | 16709260 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Saliva | 16103422 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17853512 | |
| Sys-BodyFluid | Cerebrospinal fluid | 18052119 | |
| Sys-BodyFluid | Cerebrospinal fluid | 17022648 | |
| Sys-BodyFluid | Cerebrospinal fluid | 15582749 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Plasma/Serum | 18793429 | |
| Sys-BodyFluid | Plasma/Serum | 16739989 | |
| Sys-BodyFluid | Plasma/Serum | 16104056 | |
| Sys-BodyFluid | Urine | 16281181 | |
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colorectal cancer | 22408128 | |
| HCSD | cancer(colorectal carsinoma) | 23585443 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(head and neck squamous cell carcinoma) | 22918226 | |
| HCSD | cancer(urothelial carcinoma) | 23591195 | |
| HCSD | cancer(glioblastoma multiforme) | 21574646 | |
| HCSD | cancer(breast cancer) | 24505115 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(oral cancer ) | 21714544 | |
| HCSD | cancer(gastric cancer) | 22204653 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | non-small cell lung cancer | 21262398 | |
| HCSD | cancer(non small cell lung cancer) | 19655816 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |
| HCSD | cancer(lung cancer) | 21806062 | |