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| UniProt ID |
P16066 |
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| Entry Name |
ANPRA_HUMAN |
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| Protein Name |
Atrial natriuretic peptide receptor 1 |
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| Primary Gene Name |
NPR1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Vasoactive |
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| Membrane Location |
Membrane |
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| Substrate Name | Atrial natriuretic peptide receptor | |
| Cell Type | ||
| Substrate Description | guanylate cyclase activity. receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, vasoactive hormones in cardiovascular homeostasis. | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | ||
| Sheddase | metalloendopeptidase | |
| Shedding-related Disease | cell receptor (NPR) | |
| Short Summary of Papers | proteolysis of ANF receptor by an endogenous metalloendopeptidase may inactivate guanylate cyclase activity and play a role in desensitization or down-regulation of the ANF receptor | |
| Cleavage Information | NONE | |
| PMID | 1358609 2458716 |
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Start | End |
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33 | 473 |
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474 | 494 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PAPER | No_information | metalloendopeptidase | 1358609 | |||||