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| UniProt ID |
P15941 |
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| Entry Name |
MUC1_HUMAN |
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| Protein Name |
Mucin-1 |
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| Primary Gene Name |
MUC1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function | ||
| Membrane Location |
Secreted |
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| Substrate Name | Mucin-1 (MUC1) | |
| Cell Type | human uterine epithelial cell line | |
| Substrate Description | hormone signaling | |
| Substrate Function Category | cell surface structure | |
| Substrate Function Subtype | cell surface protein (mucous); growth hormone receptor | |
| Sheddase | ADAM17, MT-MMP | |
| Shedding-related Disease | mucous barriers (cell surface protein) | |
| Short Summary of Papers | shedding of MUC1, result in MUC1 release, may be involved in turnover of MUC1 and MUC1 clearance from the uterine epithelial cell | |
| Cleavage Information | NONE | |
| PMID | 12441351 15130087 |
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Start | End |
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24 | 1158 |
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1159 | 1181 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | VVTG*SGHA | 23 | signal peptidase complex (animal) | physiologically relevant | N-terminal sequencing | 11341784 | ||
| HPRD | SGHA*SSTP | 27 | 11341784 | |||||
| HPRD | SGHA*SSTP | 27 | 11341784 | |||||
| HPRD | SGHA*SSTP | 27 | 11341784 | |||||
| HPRD | SGHA*SSTP | 27 | 11341784 | |||||
| HPRD | GLSN*IKFR | 1091 | 1556125 | |||||
| HPRD | GLSN*IKFR | 1091 | 1556125 | |||||
| HPRD | FRPG*SVVV | 1097 | 11341784 | |||||
| HPRD | FRPG*SVVV | 1097 | 11341784 | |||||
| HPRD | FRPG*SVVV | 1097 | 11341784 | |||||
| HPRD | FRPG*SVVV | 1097 | 11341784 | |||||
| MEROPS | FRPG*SVVV | 1097 | MUC1 self-cleaving mucin | physiologically relevant | NONE | 15987679 | ||
| HPRD | AFRE*GTIN | 1109 | 1556125 | |||||
| HPRD | AFRE*GTIN | 1109 | 1556125 | |||||
| PAPER | KTEA*ASRY | 1128 | ADAM17 | N-terminal sequencing | 12441351 15130087 | |||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Milk | 16502470 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Bronchoalveolar lavage fluid | 16497942 | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Plasma/Serum | 14718574 | |
| HCSD | cancer (lung cancer) | 19776420 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(pancreatic cancer) | 21625447 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(ovarian cancer) | 22623176 | |
| HCSD | cancer(Glioblastoma) | 23483059 | |
| HCSD | cancer(colorectal cancer) | 22506683 | |
| HCSD | cancer(lung cancer) | 21806062 | |