UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P15692
Entry Name

VEGFA_HUMAN
Protein Name

Vascular endothelial growth factor A
Primary Gene Name

VEGFA
Organism

Homo sapiens (Human)
Molecular Function

Mitogen
Developmental protein
Growth factor
Heparin-binding
Membrane Location

Secreted



Biological Literature Report of Shedding
Substrate Name Vascular endothelial growth factor (VEGF-165)
Cell Type
Substrate Description growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.
Substrate Function Category growth factor & growth hormone
Substrate Function Subtype
Sheddase (unknown)
Shedding-related Disease growth factor (VEGF)
Short Summary of Papers shedding of VEGF-165 from the cell surface together with other membrane components appears to be a unique feature by which some VEGF is delivered to the surroundings to exert its known biological actions.
Cleavage Information NONE
PMID 24501421



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
NO_INFO



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
MEROPS WSQA*APMA 26 signal peptidase complex (animal) physiologically relevant N-terminal sequencing 2584205   
MEROPS APMA*EGGG 30 meprin alpha subunit not physiologically relevant Mass spectroscopy 21693781   
MEROPS APMA*EGGG 30 meprin beta subunit not physiologically relevant Mass spectroscopy 21693781   
PAPER No_information (unknown) 24501421   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
NO_DATA NO_DATA NO_DATA