UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

P15529
Entry Name

MCP_HUMAN
Protein Name

Membrane cofactor protein
Primary Gene Name

CD46
Organism

Homo sapiens (Human)
Molecular Function

Host cell receptor for virus entry
Receptor
Membrane Location

Membrane



Biological Literature Report of Shedding
Substrate Name CD46
Cell Type
Substrate Description cofactor for complement factor I. protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue.
Substrate Function Category Immune and Inflammation
Substrate Function Subtype
Sheddase ADAM10
Shedding-related Disease cell surface protein
Short Summary of Papers ADAM10-mediated release of CD46 from apoptotic vesicles may represent a form of strategy to allow restricted complement activation to deal with modified self.
Cleavage Information NONE
PMID 16735514 15307194



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		35 343
Transmembrane
 		344 366



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER FSDA*CEEP 34 UNKNOWN Mass spectrometry 33796845   
ASCENT FYYK*ATVM 249 UNKNOWN subtiligase-based N-terminal sequencing 33536314   
PMAP No_information ADAM10 peptidase This entry is based on an experiment Gel electrophoresis 16735514    15307194   
PMAP No_information ADAM10 peptidase This entry is based on an experiment Gel electrophoresis 16735514    15307194   
PMAP No_information ADAM10 peptidase This entry is based on an experiment Gel electrophoresis 16735514    15307194   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
Sys-BodyFluid Plasma/Serum 14718574
HCSD cancer (lung cancer) 19776420
HCSD cancer(prostate cancer) 22908226
HCSD cancer(23 cancer cell lines) 20124221
HCSD cancer(colorectal carsinoma) 23585443
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137