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| UniProt ID |
P15514 |
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| Entry Name |
AREG_HUMAN |
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| Protein Name |
Amphiregulin |
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| Primary Gene Name |
AREG |
|
| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Cytokine |
|
| Membrane Location |
Membrane |
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| Substrate Name | amphiregulin (AREG) | |
| Cell Type | human colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC). | |
| Substrate Description | Gastrointestinal Cancers driven by secondary Bile Acids | |
| Substrate Function Category | disease | |
| Substrate Function Subtype | Disease: Cancers (Gastrointestinal) | |
| Sheddase | ADAM17 | |
| Shedding-related Disease | cancer (Gastrointestinal) | |
| Short Summary of Papers | deoxycholic acid (DCA) induced the cleavage of AREG proligand, leading to activation of EGFR signaling and tumorigenicity. | |
| Cleavage Information | NONE | |
| PMID | 24520077 |
| Substrate Name | amphiregulin (AREG) | |
| Cell Type | SCC(squamous cell carcinoma cell line), ACHN kidney cancer and TccSup bladder cancer cells | |
| Substrate Description | EGFR signaling, various signals in cell proliferation, survival and migration | |
| Substrate Function Category | growth factor & growth hormone | |
| Substrate Function Subtype | growth factor (EGF) | |
| Sheddase | ADAM17, ADAM15 | |
| Shedding-related Disease | growth factor (EGFR) | |
| Short Summary of Papers | amphiregulin shedding results in EGFR transactivation | |
| Cleavage Information | NONE | |
| PMID | 16769815 15337756 |
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Start | End |
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199 | 221 |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| PMAP | EYDN*EPQI | 89 | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 15066986 | ||
| PMAP | IVDD*SVRV | 100 | NONE | This_entry_is_based_on_an_experiment. | 15066986 3413110 | |||
| MEROPS | RVEQ*VVKP | 106 | ADAM17 peptidase | physiologically relevant | NONE | 15066986 | ||
| PMAP | RVEQ*VVKP | 106 | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 15066986 | ||
| MEROPS | KSMK*THSM | 187 | ADAM17 peptidase | not physiologically relevant | NONE | 15066986 | ||
| PMAP | KSMK*THSM | 187 | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | Mass spectrometry | 15066986 | ||
| PMAP | No_information | ADAM17 peptidase | This_entry_is_based_on_an_experiment. | Others | 12743035 | |||
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|---|---|---|---|
| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| SPD | 22728825 | ||
| HCSD | cancer (gastric cancer) | 23161554 | |
| HCSD | cancer(prostate cancer) | 22908226 | |
| HCSD | cancer(23 cancer cell lines) | 20124221 | |
| HCSD | cancer(Head and neck squamous cell carcinoma) | 23665456 | |
| HCSD | cancer(colon tumor) | 23684732 | |
| HCSD | cancer(colorectal cancer | 24418523 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |
| HCSD | cancer(Liver metastasis in colorectal cancer) | 23443137 | |
| HCSD | cancer(colorectal cancer) | 25216327 | |