UniProt Summary
UniProt ID

P15509

Entry Name

CSF2R_HUMAN

Protein Name

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Primary Gene Name

CSF2RA

Organism

Homo sapiens (Human)

Molecular Function

Receptor

Membrane Location

Secreted
Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name GM-CSFR
Cell Type monocytes
Substrate Description Leukocyte Recruitment - Cytokines and cytokine receptors involved in cell-cell communication, including firm adhesion
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cytokine receptor
Sheddase unknown
Shedding-related Disease cytokine receptor
Short Summary of Papers soluble receptor antagonist, prevent IL-1 precursor processing
Cleavage Information NONE
PMID 16565325



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
23 320
Transmembrane
321 346



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information unkown 12421947   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825
HCSD cancer(ovarian cancer) 23805888
HCSD cancer(Liver metastasis in colorectal cancer) 23443137
locate 17986452