UniProt Summary
UniProt ID

P15379

Entry Name

CD44_MOUSE

Protein Name

CD44 antigen

Primary Gene Name

Cd44

Organism

Mus musculus (Mouse)

Molecular Function

Receptor

Membrane Location

Cell membrane
Membrane




Biological Literature Report of Shedding
Substrate Name CD44
Cell Type endothelial cell, monocytes, lymphocytes, neutrophils
Substrate Description Leukocyte Recruitment, Firm adhesion and locomotion to the endothelial cell junction
Substrate Function Category Immune and Inflammation
Substrate Function Subtype Immune and Inflammation; cell adhesion molecule
Sheddase ADAM10, ADAM17, MT1MMP
Shedding-related Disease cell adhesion molecule
Short Summary of Papers de-adhesion,cell migration,transcriptional activation;dynamic regulation of the interaction between CD44 and the ECM during cell migration
Cleavage Information NONE
PMID 16565325 15197174 18951988



Cleavage Site Diagram



Topological Domains
Topological Domains
Start End
Extracellular
23 685
Transmembrane
686 706



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information (unknown metalloproteases) 11418640   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER β-Cell 23430253
PAPER macrophage 24396086
PAPER ovary 15815987
SPD 22728825