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| UniProt ID |
P15328 |
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| Entry Name |
FOLR1_HUMAN |
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| Protein Name |
Folate receptor alpha |
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| Primary Gene Name |
FOLR1 |
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| Organism |
Homo sapiens (Human) |
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| Molecular Function |
Receptor |
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| Membrane Location |
Secreted |
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| Substrate Name | folate receptor | |
| Cell Type | ||
| Substrate Description | binds to folate and reduced folic acid derivatives, mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. | |
| Substrate Function Category | transporter | |
| Substrate Function Subtype | ||
| Sheddase | metalloprotease | |
| Shedding-related Disease | folate | |
| Short Summary of Papers | conversion of membrane-associated (M-FBP) to soluble (SFBP) forms by metalloprotease-mediated cleavage. | |
| Cleavage Information | NONE | |
| PMID | 1846624 |
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Start | End |
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| Database | CutSeq | Mapped Position | Protease | Type | Evidence | PMID | ||
| MEROPS | AAMS*GAGP | 234 | glycosylphosphatidylinositol:protein transamidase | physiologically relevant | N-terminal sequencing | 18780401 | ||
| PAPER | EEVA*RFYA (region) | 226* | metalloprotease | 1846624 | ||||
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| Secretome Database | Cell Type or Body Fluid | PubMed Reference | |
| Sys-BodyFluid | Urine | 16948836 | |
| Sys-BodyFluid | Urine | 16281181 | |
| Sys-BodyFluid | Urine | 16335936 | |
| Sys-BodyFluid | Saliva | 18361515 | |
| Sys-BodyFluid | Saliva | 17614365 | |
| Sys-BodyFluid | Amniotic fluid | 17495049 | |
| Sys-BodyFluid | Milk | 12833513 | |
| HCSD | cancer(ovarian cancer) | 23805888 | |